Refined crystal structures of TNF-α and TNF mutant R31D
نویسندگان
چکیده
منابع مشابه
Serum Levels of TNF-α, TNF-αRI, TNF-αRII and IL-12 in Treated Rheumatoid Arthritis Patients
Background: Rheumatoid arthritis (RA) is a chronic multisystem autoimmune disease common in all races and ethnics. Cytokines and cytokines receptors play an important role in RA pathogenesis and clinical presentation. Objective: To investigate the serum levels of TNF-α, TNF-α RI, TNF-α RII and IL-12 in RA patients and healthy control group. Methods: In this study 43 patients fulfilling the revi...
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Mengyuan LIU*†, Xiangbin WANG†, Changcheng YIN†, Zhong ZHANG†, Qing LIN†, Yongsu ZHEN§ and Hualiang HUANG†‡1 *Faculty of Life Science, Hubei University, 430062 Wuhan, People’s Republic of China, †Beijing ABT Genetic Engineering Technology Co. Ltd., 102206 Beijing, People’s Republic of China, §The Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical S...
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Background:Brucella spp. are facultative intracellular pathogens that can cause chronic infections in many tissues and organs. Objectives: To investigate serum dermcidin, salusin-alpha, salusin-beta and TNF-alpha levels and their correlation with each other in patients with acute brucellosis. Methods: From 50 patients hospitalized upon...
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This short communication describes our research which demonstrates that TNF-α causes a rapid decline in mitochondrial function, leading to neuronal cell death. As such, this neurotoxic proinflammatory cytokine may play a role in brain damage from stroke and neurodegeneration in chronic conditions such as Alzheimer's disease (AD) and Parkinson's disease. We have extended this initial observation...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 1996
ISSN: 0108-7673
DOI: 10.1107/s0108767396091738